Hypoalbuminemia increases clot fibrin network density and impairs fibrinolysis during glomerular proteinuria

Amanda P. Waller, Ph.D., M.Sc.
Center for Clinical and Translational Research
Nationwide Children’s Hospital
Columbus, OH, U.S.

Glomerular disease-related thrombosis and the factors leading to it are poorly understood. Waller, Ph.D., M.Sc., uses this presentation to discuss findings from an investigation of the pathogenic mechanisms underlying the purported hypofibrinolytic defect. This study uses well-established rodent models and a cohort of adult and pediatric patients hypothesizing that hypofibrinolysis arises from derangements in clot architecture that lead to increased fibrin density and altered incorporation of pro-/anti-fibrinolytic proteins into clots. Results of this study reveal the regulatory role of albumin in fibrinolysis.